Chemistry and Biochemistry



Organic chemistry revolves around organic materials that play heavily into the fields of biochemistry, biology and in particular, medicine. Organic chemists analyze, break apart, and synthesize organic compounds; organic chemists may retrieve organic molecules from nature to study them in the lab. 

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Merritt B. Andrus


The Andrus Lab Group synthesizes biologically active natural products with potential for combinatorial library construction and screening. We use metal catalyzed couplings and condensations to assemble key intermediates. Libraries of structural variants are then designed and used to probe receptor bindings and improve activity. Recent work includes the synthesis of the polyene stipiamide, a new reversal agent of multidrug resistance ...

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Steven L. Castle


The Castle Research Group is focused on the total synthesis of architecturally complex bioactive natural products and peptides. The Group believes that the structures of such compounds can serve as inspiration for the invention of new organic reactions and processes.  Additionally, studies of their biological activity can increase science's understanding of their modes of action, potentially leading to the design and development of ...

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Daniel H. Ess


Click here to access the Ess Lab research website.      

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James K. Harper


The primary research goal in the Harper Lab is the NMR characterization of structure in solids that are difficult or impossible to examine by more conventional techniques. The relevance of our methods is, perhaps, best demonstrated by the Harper Lab's recent characterization of the complete crystal structure of (+)-catechin, a ubiquitous and extensively studied antioxidant that had defied characterization for nearly ...

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David J. Michaelis


The Michaelis Research Group takes a multidisciplinary approach to chemistry that enables advances not only at the interface of two fields, but also within strictly disciplinary research. This capacity derives from an acquired understanding of the scientific approach, methods, and techniques used in other disciplines to solve problems.  The Michaelis Lab intends to establish a research program that employs tools and techniques from other ...

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Matt A. Peterson


Peterson Lab studies focus on the chemical synthesis and biological evaluation of potential antitumor and/or antiviral compounds. Modification of naturally occurring nucleosides is a unifying feature in Peterson Lab research. Current interests can be broken down into three areas: (1) synthesis and evaluation of nucleoside-based enediynes (e.g., uracil-fused and uracil-linked enediynes I and II; and adenosine mimic III); (2) synthesis and evaluation of transition-state analogue ...

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Joshua L. Price


The interests of the Price Research Lab include bioorganic chemistry, protein folding and structure, protein glycosylation's energetic and structural effects, and the design of novel proteins using unnatural amino acids.

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Paul B. Savage


Savage Research Lab has two main areas of study: membrane active antibiotics and glycolipid immunology. The Savage Lab has developed small-molecule mimics of antimicrobial peptides and is working to understand better mechanisms of antibacterial activity, optimize medical device coatings containing these mimics to prevent bacterial colonization, and optimizing compound structures for varied applications. Savage researchers also work with immunostimulatory glycolipids and ...

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